Chemotherapy Research Today is a free monthly online journal that collates and summarizes the latest research about Chemotherapy, including details on cancer treatment, side effects, drugs.

The effect of atorvastatin treatment on HIV-1-infected patients interrupting antiretroviral therapy.

Negredo E, Clotet B, Puig J, Pérez-Alvarez N, Ruiz L, Romeu J, Moltó J, Rey-Joly C, Blanco J

Lluita contra la SIDA, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain.

We conducted a pilot study to assess the effect of atorvastatin on HIV replication. Patients with stable HAART-controlled infection interrupted therapy and were randomly assigned to a control group or to start atorvastatin 40 or 80 mg/day. Statin groups showed lower serum cholesterol but similar viral loads and CD4 T-cell counts to the control group at weeks 4 and 12. Paradoxically, baseline serum cholesterol, but not atorvastatin, influenced viral rebound at week 4.

Published 10 February 2006 in AIDS, 20(4): 619-21.
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