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Dose accuracy of a reusable insulin pen using a cartridge system with an integrated plunger mechanism.

Clarke A, Dain MP

sanofi-aventis, Deutschland GmbH, Industriepark Hoechst, Building K607, 65843 Frankfurt am Main, Germany. Alastair.Clarke@sanofi-aventis.com

Pen injection devices are a common method of administering insulin for patients with diabetes. Pen devices must comply with guidelines prepared by the International Organization for Standardization, which include device dose accuracy and precision. OptiClik (sanofi-aventis) was developed to fulfil unmet needs of patients with diabetes, including: easier cartridge changing, clearer dose display and readability, and a larger dose of insulin to be delivered with a single injection. In this paper, the authors report on the dose accuracy of the OptiClik pen device, which uses a novel cartridge system with an integrated plunger for easier cartridge changing. The authors show that OptiClik accurately delivers a required dose of insulin, which is maintained over the lifetime of the pen. OptiClik offers a significant contribution to the treatment of diabetes.

Published 4 September 2006 in Expert Opin Drug Deliv, 3(5): 677-83.
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