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Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum.

Boxell A, Lee SH, Jefferies R, Watt P, Hopkins R, Reid S, Armson A, Ryan U

Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia.

This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.

Published 5 May 2008 in Exp Parasitol, 119(2): 301-3.
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